The Knowledge Center will create a knowledge network to integrate knowledge generated by Common Fund Programs. Visit the CFDE knowledge portal to learn more.
CFDE Engagement Award: OD036440
The Training Center will coordinate training efforts for the CFDE consortium to enable researchers, regardless of experience, to engage with CFDE tools and resources.
CFDE Engagement Award: OD037922
The Cloud Workspace Implementation Center (CWIC) will support cloud computing activities in select cloud workspaces.
CFDE Engagement Award: OD037936
The Data Resource Center (DRC) maintains a portal to enable users to query and use the data sets and other digital resources from across Common Fund programs. Visit the CFDE data resource portal to learn more.
CFDE Engagement Award: OD036435
The Integration and Coordination Center will support integrating CFDE-related activities between the CFDE Centers and Common Fund data coordinating.
The Somatic Mosaicism across Human Tissues (SMaHT) Network aims to transform our understanding of how somatic mosaicism in human cells influences biology and disease. Visit the SMaHT program page (Somatic Mosaicism across Human Tissues (SMaHT) | NIH Common Fund) to learn more.
The Stimulating Peripheral Activity to Relieve Conditions (SPARC) program seeks to accelerate development of therapeutic devices that modulate electrical activity in nerves to improve organ function. Visit the SPARC program page and the SPARC Portal to learn more.
CFDE Engagement Award: OD030164
Metabolomics is the study of the chemical reactions that occur in organisms, cells, or tissues and the small chemicals (metabolites) that are produced as a result. The Metabolomics program aims to catalyze science around the role of metabolomics in human health. Visit the Metabolomics program page and the Metabolomics Workbench to learn more.
CFDE Engagement Award: OD030544
The goal of the Common Fund’s Glycoscience program is to create new resources, tools, and method to make the study of glycans (sugars) more accessible to the broader research community. Visit the Glycoscience program page and the GlyGen webpage to learn more.
CFDE Engagement Award: OD032092
The goal of the 4D Nucleome Data (4DN) program is to study the three-dimensional organization of the nucleus in space and time (the 4th dimension). Visit the 4DN program page and the 4D Nucleome Web Portal to learn more.
CFDE Engagement Award: OD032119
The Human Microbiome Project (HMP) developed research resources to enable the study of the microbial communities that live in and on our bodies and the roles they play in human health and disease. Visit the HMP program page and the HMP Data Portal to learn more.
The Genotype-Tissue Expression (GTEx) program established a data resource and tissue bank to study the relationship between genetic variants (inherited changes in DNA sequence) and gene expression (how genes are turned on and off) in multiple human tissues and across individuals. GTEx is also examining how gene expression varies between male and female. Visit the GTEx program page and the GTEx Portal to learn more.
CFDE Engagement Award: OD030161
The Cellular Senescence Network (SenNet) program was established to comprehensively identify and characterize the differences in senescent cells across the body, across various states of human health, and across the lifespan. Visit the SenNet program page to learn more.
The goal of the Bridge to Artificial Intelligence (Bridge2AI) program is to propel biomedical research forward by setting the stage for widespread adoption of artificial intelligence (AI) that tackles complex biomedical challenges beyond human intuition. Visit the Bridge2AI program page to learn more.
The goal of the Human BioMolecular Atlas Program (HuBMAP) is to develop an open and global platform to map healthy cells in the human body. Visit the HuBMAP program page and the HuBMAP Consortium webpage to learn more.
CFDE Engagement Award: OD030545
The Extracellular RNA Communication (ExRNA) program is working to understand extracellular RNA biology and accelerate development of potential therapeutics and diagnostics. Visit the ExRNA program page and the ExRNA Research Portal to learn more.
CFDE Engagement Award: OD030547
The Molecular Transducers of Physical Activity Consortium (MoTrPAC) aims to uncover at the molecular level how exercise improves and preserves the health of the body’s tissues and organs. Visit the MoTrPAC program page and MoTrPAC Data Hub to learn more.
The goal of the Gabriella Miller Kids First Pediatric Research Program (Kids First) is to help researchers uncover new insights into the biology of childhood cancer and structural birth defects, including the discovery of shared genetic pathways between these disorders. Visit the Kids First program page and the Kids First Data Resource Portal to learn more.
CFDE Engagement Award: OD030162
The Nutrition for Precision Health (NPH), powered by the All of Us Research Program, aims to develop algorithms that predict individual responses to food and dietary patterns. Visit the NPH program page (Nutrition for Precision Health, powered by the All of Us Research Program | NIH Common Fund) to learn more.
The goal of the Illuminating the Druggable Genome (IDG) program is to identify and provide information on proteins that are currently not well studied within commonly drug-targeted protein families. Visit the IDG program page and the IDG Consortium to learn more.
CFDE Engagement Award: OD030546
The Library of Integrated Network-based Cellular Signatures (LINCS) program is developing a library that catalogs changes that occur when different types of cells are exposed to a variety of agents that disrupt normal cellular functions, called “perturbagens.” Visit the LINCS program page and the LINCS Consortium to learn more.
CFDE Engagement Award: OD030160
The Community Partnerships to Advance Science for Society (ComPASS) Program goals are to 1) develop, share, and evaluate community-led health equity structural interventions that leverage partnerships across multiple sectors to reduce health disparities and 2) develop a new health equity research model for community-led, multisectoral structural intervention research across NIH and other federal agencies. Visit the ComPASS program page (Community Partnerships to Advance Science for Society (ComPASS) | NIH Common Fund) for more information.
The Acute to Chronic Pain Signatures (A2CPS) program aims to develop a set of objective biomarkers that provide “signatures” to predict if chronic pain is likely to develop or be resolved after acute pain, like an injury or after a surgery. Visit the A2CPS program page and the A2CPS website to learn more.